雜志名稱：Advanced Science
影響因子：14.3
文章題目：A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing
DOI：https://doi.org/10.1002/advs.202414161
第一作者：Bangguo Zhou, Yangying Duan, Wenhao Li, Tao Chen, Jincheng Wang, Manting Cao, Guohao Lin, Ke Yang, Zhangqi Lai, Wencheng Wu
作者單位：
四川醫(yī)學(xué)科學(xué)院四川省人民醫(yī)院中國電子科技大學(xué)
浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院
浙江中醫(yī)藥大學(xué)第三臨床醫(yī)學(xué)院
引用YOBIBIO產(chǎn)品：
Calcein,4,6-diamidino-2-phenylindole (DAPI)
propidium iodide (PI)
fluorescein isothiocyanate (FITC)
Superior Fetal bovine serum（U11-020A)
cell counting Kit-8 (CCK-8)
文章摘要：
The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is developed to promote diabetic wound healing. This dressing is constructed by co-loading gold-cerium oxide (AuCeO2) dumbbells and glucose oxidase (GOx) into a reactive oxygen species (ROS)-sensitive hydrogel matrix (ACG gels). In this system, Au-CeO2 dumbbells effectively eliminate ROS, protecting cells from oxidative stress-induced damage while exhibiting significant near-infrared photothermal antibacterial activity. Additionally, the controlled release of GOx decreases blood glucose levels in the wound microenvironment, alleviating oxidative stress and inhibiting bacterial growth proliferation, thereby expediting the healing process. ACG gels demonstrated excellent wound healing-promoting properties in two in vivo wound models, providing a promising and effective platform for diabetic wound management.
慢性糖尿病傷口的管理是一項(xiàng)復(fù)雜的挑戰(zhàn)，需要局部血糖調(diào)節(jié)、炎癥水平調(diào)節(jié)和預(yù)防細(xì)菌感染。因此，開發(fā)了一種具有抗氧化、局部糖控制和抗菌特性的多功能傷口敷料，以促進(jìn)糖尿病傷口愈合。該敷料是通過將氧化金鈰 （AuCeO2） 啞鈴和葡萄糖氧化酶 （GOx） 共同加載到活性氧 （ROS） 敏感的水凝膠基質(zhì) （ACG 凝膠） 中構(gòu)建的。在該系統(tǒng)中，Au-CeO2 啞鈴有效消除 ROS，保護(hù)細(xì)胞免受氧化應(yīng)激誘導(dǎo)的損傷，同時(shí)表現(xiàn)出顯著的近紅外光熱抗菌活性。此外，GOx 的受控釋放可降低傷口微環(huán)境中的血糖水平，減輕氧化應(yīng)激并抑制細(xì)菌生長增殖，從而加速愈合過程。ACG 凝膠在兩種體內(nèi)傷口模型中表現(xiàn)出優(yōu)異的促進(jìn)傷口愈合特性，為糖尿病傷口管理提供了一個(gè)有前途且有效的平臺(tái)。
