雜志名稱：Journal of Controlled Release
影響因子：10.5
文章題目：A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking
DOI: https://doi.org/10.1016/j.jconrel.2025.02.011
第一作者：Yinying Pu, Yangying Duan, Wenhao Li, Han Lin, Qiyue Li, Binxu Yin, Kun Zhang, Bangguo Zhou, Wencheng Wu
作者單位：
中國電子科技大學(xué)
四川省人民醫(yī)院四川醫(yī)學(xué)科學(xué)院
中國科學(xué)院上海硅酸鹽研究所
浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院
引用YOBIBIO產(chǎn)品：
Calcein,4,6-diamidino-2-phenylindole (DAPI)
propidium iodide (PI)
fluorescein isothiocyanate (FITC)
Superior Fetal bovine serum（U11-020A)
cell counting Kit-8 (CCK-8)
文章摘要：
Reactive oxygen species (ROS) play a major role in driving acute kidney injury (AKI) by causing oxidative stress and triggering inflammatory responses. However, treatment of AKI with traditional nanomedicines is still challenging because of low ROS scavenging efficacy and poor inflammatory chemotactic. Herein, we have constructed a novel cerium single-atom catalyst (A-CeSACs) for AKI catalytic therapy which targets inflammation and mimics several enzymatic redox activities. After injection of A-CeSACs into AKI mice via tail vein, targeting damaged kidney sites is realized by hitchhiking neutrophils that naturally target sites of inflammation via chemotaxis. After entering the AKI inflammatory environment, A-CeSACs rapidly scavenge multiple ROS via the Ce3+/Ce4+ redox reaction, thus reducing the release of inflammatory factors. The designed A-CeSACs displayed remarkably catalytic therapy efficacy in glycerol-induced AKI mice models. Overall, the present study describes a novel therapeutic strategy for targeted AKI catalytic therapy that is also potentially applicable to other inflammation-related diseases.
活性氧 （ROS） 通過引起氧化應(yīng)激和觸發(fā)炎癥反應(yīng)，在驅(qū)動急性腎損傷 （AKI） 中起主要作用。然而，由于 ROS 清除效率低且炎癥趨化性差，使用傳統(tǒng)納米藥物治療 AKI 仍然具有挑戰(zhàn)性。在此，我們構(gòu)建了一種用于 AKI 催化治療的新型鈰單原子催化劑 （A-CeSACs），它靶向炎癥并模擬幾種酶促氧化還原活性。通過尾靜脈將 A-CeSACs 注射到 AKI 小鼠中后，通過搭便車中性粒細(xì)胞來實(shí)現(xiàn)靶向受損腎臟部位，中性粒細(xì)胞通過趨化性自然靶向炎癥部位。進(jìn)入 AKI 炎癥環(huán)境后，A-CeSACs 通過 Ce3+/Ce4+ 氧化還原反應(yīng)快速清除多個 ROS，從而減少炎癥因子的釋放。設(shè)計的 A-CeSACs 在甘油誘導(dǎo)的 AKI 小鼠模型中顯示出顯著的催化治療效果�？傮w而言，本研究描述了一種靶向 AKI 催化治療的新型治療策略，該策略也可能適用于其他炎癥相關(guān)疾病。
