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用于免疫代謝癌癥治療的光活化免疫刺激性納米藥物
雜志名稱：Journal of the American Chemical Societ
影響因子：15.0
文章題目：Photoactivatable Immunostimulatory Nanomedicine for Immunometabolic Cancer Therapy
文獻地址：https://doi.org/10.1021/jacs.2c07872
第一作者：Wencheng Wu, Yinying Pu, Bangguo Zhou, Yucui Shen, Shuang Gao, Min Zhou, Jianlin Shi
作者單位：
中國科學院上海陶瓷研究所高性能陶瓷與超細微結構國家重點實驗室；
中國醫(yī)學科學院上海納米催化醫(yī)學重大疾病專項治療研究中心；
上海市第十人民醫(yī)院醫(yī)學超聲科；
同濟大學腫瘤防治中心超聲研究與教育研究所；
同濟大學醫(yī)學院；
上海同濟大學第四人民醫(yī)院消化內鏡中心
引用產品：
Phosphate buffer solution (PBS) 
Dulbecco's modified eagle medium (DMEM)
calcein, 4, 6-diamidino-2-phenylindole (DAPI)
propidium iodide (PI)
fluorescein isothiocyanate (FITC)  
cell counting Kit-8 (CCK-8) 
文章摘要：

A rationally designed immunostimulant (CC@SiO₂-PLG) with a photoactivatable immunotherapeutic function for synergetic tumor therapy is reported. This CC@SiO₂-PLG nanoplatform comprises catalase and a photosensitizer (Ce6) co-encapsulated in a silica capsule, to which an immunostimulant is conjugated through a reactive oxygen species-cleavable linker. After accumulating in tumor tissue, CC@SiO₂-PLG generates O₂ to relieve tumor hypoxia and promotes the production of singlet oxygen (¹O₂) upon laser irradiation, resulting in not only tumor destruction but also the release of tumor-associated antigens (TAAs). Simultaneously, the linker breakage by the photoproduced ¹O₂ leads to the remote-controlled release of conjugated indoleamine 2,3-dioxygenase (IDO) inhibitor from CC@SiO₂-PLG and consequent immunosuppressive tumor microenvironment reversion. The released TAAs in conjunction with the inhibition of the IDO-mediated tryptophan/kynurenine metabolic pathway induced a boosted antitumor immune response to the CC@SiO₂-PLG-mediated phototherapy. Therefore, the growth of primary/distant tumors and lung metastases in a mouse xenograft model was greatly inhibited, which was not achievable by phototherapy alone.