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氫化硅納米片制備水致氫高效抗炎
雜志名稱(chēng)：Journal of the American Chemical Societ
影響因子：15.0
文章題目：Water-Enabled H2 Generation from Hydrogenated Silicon Nanosheets for Efficient Anti-Inflammation
文獻(xiàn)地址：https://doi.org/10.1021/jacs.2c04412
第一作者：Yanling You , Ya-Xuan Zhu , Junjie Jiang , Min Wang , Zhixin Chen , Chenyao Wu , Jie Wang , Wujie Qiu , Deliang Xu , Han Lin , Jianlin Shi
作者單位：
中國(guó)科學(xué)院上海陶瓷研究所高性能陶瓷與超微結(jié)構(gòu)國(guó)家重點(diǎn)實(shí)驗(yàn)室
中國(guó)醫(yī)學(xué)科學(xué)院重大疾病特異性治療納米催化藥物研究單位
上海市第十人民醫(yī)院，
上海納米催化醫(yī)學(xué)前沿科學(xué)中心
同濟(jì)大學(xué)醫(yī)學(xué)院
中國(guó)科學(xué)院大學(xué)材料科學(xué)與光電子工程中心
上海中醫(yī)藥大學(xué)
引用產(chǎn)品：
Rat NGF Beta 生長(zhǎng)因子β
Dulbecco’s modified eagle’s medium (DMEM, high glucose) DMEM高糖培養(yǎng)基
Roswell Park Memorial Institute (RPMI) 1640 medium RPMI 1640培養(yǎng)基
fetal bovine serum (FBS), PBS 胎牛血清
penicillin/streptomycin 青鏈霉素雙抗
文章摘要：
As an emerging therapeutic gas, hydrogen (H2) is gifted with excellent biosafety, high tissue permeability, and radical-trapping capacity and is extensively considered as a highly promising antioxidant in clinics. However, a facile and effective strategy of H2 production for major inflammatory disease treatments is still lacking. In this study, by a facile wet-chemical exfoliation synthesis, a hydrogen-terminated silicon nanosheet (H-silicene) has been synthesized, which can favorably react with environmental water to generate H2 rapidly and continuously without any external energy input. Furthermore, theoretical calculations were employed to reveal the mechanism of enhanced H2 generation efficacy of H-silicene nanosheets. The as-synthesized H-silicene has been explored as a flexible hydrogen gas generator for efficient antioxidative stress application for the first time, which highlights a promising prospect of this two-dimensional H-silicene nanomaterial for acute inflammatory treatments by on-demand H2 production-enabled reactive oxygen species scavenging. This study provides a novel and efficient modality for nanomaterial-mediated H2 therapy.
作為一種新興的治療氣體，氫氣(H2)具有優(yōu)異的生物安全性、高組織滲透性和自由基捕獲能力，并被廣泛認(rèn)為是臨床上非常有前途的抗氧化劑。然而，H2主要炎癥疾病治療藥物的生產(chǎn)仍然缺乏。在本研究中，通過(guò)一種簡(jiǎn)單的濕化學(xué)剝離合成法，合成了氫封端的硅納米片(H-硅烯),它可以很好地與環(huán)境水反應(yīng)生成H2無(wú)需任何外部能量輸入。此外，通過(guò)理論計(jì)算揭示了H增強(qiáng)的機(jī)理2H-硅烯納米片的生成效率。首次探索了合成的H-硅烯作為有效抗氧化應(yīng)激應(yīng)用的柔性氫氣發(fā)生器，這突出了這種二維H-硅烯納米材料通過(guò)按需H2生產(chǎn)性活性氧清除。這項(xiàng)研究為納米材料介導(dǎo)的氫原子轉(zhuǎn)移提供了一種新穎有效的方式2治療。
